The opening shot is a panorama of Los Angeles, revealing a city where all of the buildings and inhabitants are some form of commercial branding: birds in the form of the Bentley and Aston Martin logos, MSN’s butterfly, pedestrians in the shape of the AIM icon, overhead highway signs mounted on Atlantic Records logos, etc.
The Pringles mascot (voiced by David Fincher) pulls into a restaurant parking lot and propositions an Esso Girl waitress (voiced by Aja Evans) who’s on a smoke break. Two Michelin Man cops in a parked cruiser (voiced by Bob Stephenson and Sherman Augustus) are introduced as they debate the morality of keeping animals in zoos. Across town, Bob’s Big Boy (voiced by Joel Michaely) and Haribo (voiced by Matt Winston) are on a tour at the zoo led by a flamboyant Mr Clean (voiced by Michaely). The two boys hate the tour and hop off the tour train. They soon begin to harass the MGM lion by mooning it and throwing a Coca-Cola bottle at it, but they are scolded by zoo security, the Green Giant.
As the cops order lunch, a call comes in over the radio about a criminal on the loose in a red delivery truck. Both cops spy Ronald McDonald (voiced by Stephenson) in the truck and give chase. The pursuit quickly veers out of control, as innocent bystanders are put in danger. Meanwhile, the kids at the zoo have finished their visit and are back on the school bus, soon nearing the Pizza Hut where Esso Girl is waiting on the Original Pringles mascot and the Pringles Hot & Spicy mascot. Ronald McDonald swerves to avoid the school bus and tips his truck over in front of the Pizza Hut. Several guns and biological weapons spill out of the back of the truck, tempting Big Boy and Haribo to steal them for sale on the black market. Ronald McDonald knocks out Haribo with his foot, takes Big Boy hostage, and runs into the Pizza Hut. Inside, Big Boy bites Ronald McDonald and runs for cover behind the counter with Esso Girl. Enraged, Ronald McDonald opens fire, giving the police the excuse to start firing on him, and he kills one of the police officers.
As the gun battle explodes into the streets, a low rumbling can be heard across the entire city. A giant earthquake opens a fissure in the shape of Microsoft’s Xbox video game console logo, which splits the streets of the city open. Big Boy and Esso Girl escape the rapidly crumbling Pizza Hut and steal a cop car. While running from the police on a stolen Grease 2 motorcycle, Ronald McDonald runs into a fallen Weight Watchers sign and is thrown off, sliding into a crevasse shaped like the Zenith logo. As he tries to pull himself out, he is run over by Esso Girl and Big Boy’s car. The duo barely escape the city, speeding along a curved highway shaped like the VAIO logo. As they near the Hollywood chewing gum Hollywood sign, it falls apart, sending the giant letters crashing onto the highway in front of them. While evading one of the letters, they veer off the highway and down a hill, crashing into a tree. Crude oil erupts from the rifts around town and floods Los Angeles. The hill that Esso Girl and Big Boy are on splits in two, revealing a giant North Face logo. Eventually, the land crumbles around them, swallowed by the sea, leaving them on a tiny island together (with Esso Girl picking up a coloured Apple and taking a bite). The film closes by zooming out to reveal that California has been separated from mainland and is now shaped like the Nike logo, but also that the entire universe is made up of even more logos. After the credits, a bald, black-eyed, and partly toothless Ronald McDonald laughs menacingly and says, “I’m lovin’ it.”